James MacLeod
Director, UK Ag Equine Programs, Professor
Scholars@UK
Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression
Cullen, J. N., Cieslak, J., Petersen, J. L., Bellone, R. R., Finno, C. J., Kalbfleisch, T. S., Calloe, K., Capomaccio, S., Cappelli, K., Coleman, S. J., Distl, O., Durward-Akhurst, S. A., Giulotto, E., Hamilton, N. A., Hill, E. W., Katz, L. M., Klaerke, D. A., Lindgren, G., MacHugh, D. E. & Mackowski, M. & 15 others, , Sep 2025, In: PLoS Genetics. 21, 9 September, e1011835.Research output: Contribution to journal › Article › peer-review
PPARγ Agonism Modulates Synovial Macrophage and Cartilage Responses in an Equine Model of Synovial Inflammation—Implications for Joint Therapy
Chaimbeul, S. F., Rodrigues, N. N. P., Thurston, D. D., Scoggin, K. E., Janes, J., Jacobs, C. A., MacLeod, J. N., Stone, A. V. & Menarim, B. C., Sep 2025, In: Biomolecules. 15, 9, 1267.Research output: Contribution to journal › Article › peer-review
Donor age effects on in vitro chondrogenic and osteogenic differentiation performance of equine bone marrow- and adipose tissue-derived mesenchymal stromal cells
Bagge, J., Berg, L. C., Janes, J. & MacLeod, J. N., Dec 2022, In: BMC Veterinary Research. 18, 1, 388.Research output: Contribution to journal › Article › peer-review
Advances in gene ontology utilization improve statistical power of annotation enrichment
Hinderer, E. W., Flight, R. M., Dubey, R., MacLeod, J. N. & Moseley, H. N. B., 2019, In: PLoS ONE. 14, 8, p. e0220728Research output: Contribution to journal › Article › peer-review
Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis
Menarim, B. C., El-Sheikh Ali, H., Loux, S. C., Scoggin, K. E., Kalbfleisch, T. S., MacLeod, J. N. & Dahlgren, L. A., Dec 8 2021, In: Frontiers in Immunology. 12, 734322.Research output: Contribution to journal › Article › peer-review
Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair
Menarim, B. C., MacLeod, J. N. & Dahlgren, L. A., 2021, In: World Journal of Stem Cells. 13, 7, p. 825-840 16 p.Research output: Contribution to journal › Article › peer-review
Gazelle: Transcript abundance query against large-scale RNA-seq experiments
Zhang, X., Yu, Y., Mok, C. H., MacLeod, J. N. & Liu, J., Jan 18 2021, Proceedings of the 12th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2021. (Proceedings of the 12th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2021).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Kinetics of Gene Expression Changes in Equine Fetal Interzone and Anlagen Cells Over 14 Days of Induced Chondrogenesis
Mok, C. H. & MacLeod, J. N., Aug 9 2021, In: Frontiers in Veterinary Science. 8, 722324.Research output: Contribution to journal › Article › peer-review
Cellular Proliferation of Equine Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells Decline With Increasing Donor Age
Bagge, J., MacLeod, J. N. & Berg, L. C., Dec 10 2020, In: Frontiers in Veterinary Science. 7, 602403.Research output: Contribution to journal › Article › peer-review
“Adopt-a-Tissue” Initiative Advances Efforts to Identify Tissue-Specific Histone Marks in the Mare
Kingsley, N. B., Hamilton, N. A., Lindgren, G., Orlando, L., Bailey, E., Brooks, S., McCue, M., Kalbfleisch, T. S., MacLeod, J. N., Petersen, J. L., Finno, C. J. & Bellone, R. R., Mar 26 2021, In: Frontiers in Genetics. 12, 649959.Research output: Contribution to journal › Article › peer-review
Comparison of poly-A+ selection and rRNA depletion in detection of lncRNA in two equine tissues using RNA-seq
Dahlgren, A. R., Scott, E. Y., Mansour, T., Hales, E. N., Ross, P. J., Kalbfleisch, T. S., MacLeod, J. N., Petersen, J. L., Bellone, R. R. & Finno, C. J., Sep 2020, In: Non-coding RNA. 6, 3, 32.Research output: Contribution to journal › Article › peer-review
Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript
Urbanek, M., MacLeod, J. N., Cooke, N. E. & Liebhaber, S. A., Feb 1992, In: Molecular Endocrinology. 6, 2, p. 279-287 9 p.Research output: Contribution to journal › Article › peer-review
Structural and functional analysis of intra-articular interzone tissue in axolotl salamanders
Cosden-Decker, R. S., Bickett, M. M., Lattermann, C. & MacLeod, J. N., Nov 2012, In: Osteoarthritis and Cartilage. 20, 11, p. 1347-1356 10 p.Research output: Contribution to journal › Article › peer-review
Corticosteroids alter the differentiated phenotype of articular chondrocytes
Fubini, S. L., Todhunter, R. J., Burton-Wurster, N., Vernier-Singer, M. & MacLeod, J. N., 2001, In: Journal of Orthopaedic Research. 19, 4, p. 688-695 8 p.Research output: Contribution to journal › Article › peer-review
Genetics, Genomics, and Emergent Precision Medicine 12 Years After the Equine Reference Genome Was Published
MacLeod, J. N. & Kalbfleisch, T. S., Aug 2020, In: Veterinary Clinics of North America - Equine Practice. 36, 2, p. 173-181 9 p.Research output: Contribution to journal › Review article › peer-review
Repetitive blood sampling in unrestrained and unstressed mice using a chronic indwelling right atrial catheterization apparatus.
MacLeod, J. N. & Shapiro, B. H., Oct 1988, In: Laboratory Animal Science. 38, 5, p. 603-608 6 p.Research output: Contribution to journal › Article › peer-review
Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy
McGivney, B. A., Eivers, S. S., MacHugh, D. E., MacLeod, J. N., O'Gorman, G. M., Park, S. D. E., Katz, L. M. & Hill, E. W., Dec 30 2009, In: BMC Genomics. 10, 638.Research output: Contribution to journal › Article › peer-review
Comparison of magnetic resonance imaging with standing cervical radiographs for evaluation of vertebral canal stenosis in equine cervical stenotic myelopathy
Janes, J. G., Garrett, K. S., Mcquerry, K. J., Pease, A. P., Williams, N. M., Reed, S. M. & Macleod, J. N., Nov 1 2014, In: Equine Veterinary Journal. 46, 6, p. 681-686 6 p.Research output: Contribution to journal › Article › peer-review
Inflamed synovial fluid induces a homeostatic response in bone marrow mononuclear cells in vitro: Implications for joint therapy
Menarim, B. C., Gillis, K. H., Oliver, A., Mason, C., Werre, S. R., Luo, X., Byron, C. R., Kalbfleisch, T. S., MacLeod, J. N. & Dahlgren, L. A., Mar 1 2020, In: FASEB Journal. 34, 3, p. 4430-4444 15 p.Research output: Contribution to journal › Article › peer-review
Strain independent elevation of hepatic mono-oxygenase enzymes in female mice
Macleod, J. N., Peter Sorensen, M. & Shapiro, B. H., 1987, In: Xenobiotica. 17, 9, p. 1095-1102 8 p.Research output: Contribution to journal › Article › peer-review
Polyacrylamide for Joint Therapy - Critical Things Unknown
Carvalho Menarim, B. (PI), Adam, E. (CoI), Janes, J. (CoI), MacLeod, J. (CoI) & Scoggin, K. (CoI)
Grayson Jockey Club Research Foundation Inc
7/1/24 → 6/30/26
Project: Research project
ARRA: Exon Splice Pattern Characterization of the Whole mRNA Transcriptome
Liu, J. (PI), Bathke, A. (CoI), MacLeod, J. (CoI) & Stromberg, A. (CoI)
8/1/09 → 8/1/09
Project: Research project
ARRA: REU Exon Splice Pattern Characterization of the Whole mRNA Transcriptome
Liu, J. (PI), MacLeod, J. (CoI), Stromberg, A. (CoI) & Bathke, A. (Former CoI)
8/1/09 → 7/31/13
Project: Research project
ARRA: Exon Splice Pattern Characterization of the Whole mRNA Transcriptome
MacLeod, J. (PI)
8/1/09 → 7/31/13
Project: Research project
Safety and Anti-inflammatory Efficacy of Glucocorticoids for Intra-articular Therapy in Racehorses
MacLeod, J. (PI)
7/1/10 → 10/31/12
Project: Research project
Orthopaedic Pathology and Genetic Associations in Cervical Stenotic Myelopathy
MacLeod, J. (PI)
9/1/09 → 8/31/12
Project: Research project
Orthopaedic Pathology and Genetic Associations with Cervical Stenotic Myelopathy
MacLeod, J. (PI)
Grayson Jockey Club Research Foundation Inc
4/1/10 → 8/31/13
Project: Research project
Genes and Genetic Mechanisms Modulating Maturation and Repair of Articular Cartilage and Responses to Intra-Articular Glucocorticoid Therapy
MacLeod, J. (PI)
6/30/08 → 10/31/12
Project: Research project
ARRA: Exon Splice Pattern Characterization of the Whole mRNA Transcriptome
Liu, J. (PI), MacLeod, J. (CoI), Stromberg, A. (CoI) & Bathke, A. (Former CoI)
8/1/09 → 7/31/13
Project: Research project
Program in Equine Medical Genetics (subcontract)
Bailey, E. (PI), Lear, T. (CoI) & MacLeod, J. (CoI)
11/1/07 → 10/31/12
Project: Research project
Articular Cartilage Maturation and Repair (Postdoctoral Fellowship for Michael Mienaltowski)
MacLeod, J. (PI) & Mienaltowski, M. (CoI)
9/1/06 → 8/31/08
Project: Research project
Horse Genomics: Linear Mapping and Microarray Development
Bailey, E. (PI), Lear, T. (CoI) & MacLeod, J. (CoI)
9/1/05 → 8/31/08
Project: Research project
Cartilage-Specific Fibronectin Isoform and Osteoarthritis
MacLeod, J. (PI)
5/1/03 → 6/30/04
Project: Research project
Characterizing Compositional and Mechanical Changes of Equine Proximal Sesamoid Bone Associated with Catastrophic Race Failure
Janes, J. (PI), Kennedy, L. (CoI), Lima, F. (CoI), MacLeod, J. (CoI), Malluche, H. (CoI), Pienkowski, D. (CoI) & Zhang, G. (CoI)
3/1/19 → 2/28/20
Project: Research project
Comparative Chondrogenic Potential of Equine Fetal Progenitor Cells and Adult Mesenchymal Stem Cells
MacLeod, J. (PI)
American College of Veterinary Surgeons
4/1/16 → 3/31/17
Project: Research project
Developmental Progenitor Cells of Articular Cartilage
MacLeod, J. (PI)
5/12/16 → 5/11/20
Project: Research project
Unique patterns of gene expression in articular chondrocytes: important insight for joint surface lesion repair and cell-based therapies
MacLeod, J. (PI)
12/1/13 → 6/30/16
Project: Research project
Safety and Anti-inflammatory Efficacy of Glucocorticoids for Intra-articular Therapy in Racehorses
MacLeod, J. (PI)
11/1/12 → 6/30/13
Project: Research project
Identification of Genetic Factors Responsible for Establishment of Equine Arteritis Virus Carrier State in Stallions.
Timoney, P. (PI), Bailey, E. (CoI), Cook, R. (CoI), Horohov, D. (CoI), MacLeod, J. (CoI), Squires, E. (CoI), Troedsson, M. (CoI), Balasuriya, U. (Former PI) & Artiushin, S. (Former CoI)
National Institute of Food and Agriculture
1/1/13 → 12/31/18
Project: Research project
Education
Ph.D., Pathology, University of Pennsylvania, 1990
VMD, Veterinary Medicine, University of Pennsylvania, 1984
